Paroxysmal nocturnal haemoglobinuria: nature's gene therapy?

Paroxysmal nocturnal haemoglobinuria (PNH) manifesting on CT as a pathologic segment of small bowel

Paroxysmal nocturnal haemoglobinuria, a rare, acquired, life-threatening disease of the blood, is characterised by a triad of haemolysis previously believed to occur mainly at night, bone marrow dysfunction, and thrombophilia. Paroxysmal nocturnal haemoglobinuria is customarily regarded to manifest clinically as haemolytic anaemia and haemoglobinuria experienced as reddened urine in the morning...

Anti-complement C5 therapy with eculizumab for the treatment of Paroxysmal Nocturnal Haemoglobinuria and Atypical Haemolytic Uraemic Syndrome

Adult hypertrophic pyloric stenosis N . A . M . SALMO N . T . MAKKI

MANCHESTER, R.C. (1945) Chronic haemolytic anaemia with paroxysmal nocturnal haemoglobinuria. Ann. intern. Med. 23, 935. MARKS, J. (1949) The Marchiafava Micheli syndrome. Quart. J. Med. 18, 105. NUSSEY, A.M. & DAWSON, D.W. (1956) Paroxysmal nocturnal haemoglobinuria. Case study, including evidence of affection of the marrow in the disease. Blood, 11, 757. SCOTT, R.B., ROBB-SMITH, A.H.T. & SCOW...

Cerebral Venous Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

Dural sinus thrombosis developed in two young women with paroxysmal nocturnal haemoglobinuria (PNH). The incidence, the clinical presentation, the radiologic findings, the therapy and the pathophysiology of haemolysis and thrombosis are discussed.

Adult hypertrophic pyloric stenosis.

MANCHESTER, R.C. (1945) Chronic haemolytic anaemia with paroxysmal nocturnal haemoglobinuria. Ann. intern. Med. 23, 935. MARKS, J. (1949) The Marchiafava Micheli syndrome. Quart. J. Med. 18, 105. NUSSEY, A.M. & DAWSON, D.W. (1956) Paroxysmal nocturnal haemoglobinuria. Case study, including evidence of affection of the marrow in the disease. Blood, 11, 757. SCOTT, R.B., ROBB-SMITH, A.H.T. & SCOW...